Cultural differences and similarities are examined that affect innovation processes in India, China, and Singapore. China and India are two giant economic powers that are important for the development of the world. All three countries emphasise in their public statements their wish to increase their innovative ability. However, there are differences in innovative abilities between these countries. One potential reason for differences may be cultural. However, cultural differences do not just affect differences in innovation processes. They also may affect in a subtle way specific strategies and ideas to increase innovations, e.g., in R&D teams. Thus, cross-cultural differences are important – however, as far as we know cross-cultural psychological studies have not been done comparing these three countries. We use the GLOBE study as a starting point to develop hypotheses on how cross-cultural differences affect these three countries. The GLOBE study examines nine cultural difference variables and is the newest and methodologically the best developed cross-cultural study (based on more than 17,000 responses from mid-level managers in 61 countries. The study will be an important addition to the burgeoning literature on innovation and contribute greatly to cross-cultural studies. It also fills a gap of studies based in Asia and with contribution to Asian businesses.