A collaboration with Assistant Professor Fan Qiao of Duke-NUS Medical School, we plan apply the genome-wide association study (GWA study, or GWAS) approach to identify genetic variants in association with occupational well-being indices, such as survey measures of happiness, job satisfaction, and psychological distress. Furthermore, occupational characteristics, such as job complexity, will be used in conjunction with genetic markers, to examine the gene-environment interaction. For this study, we will study data collected from the UK Biobank, a research project that recruited more than half a million people aged between 40-69 years between 2006 and2010 across the UK. The UK Biobank project is unique because it covers a very broad range of areas such as genetics, health, social relationship, eating behaviours, and work.