Research on the work-home interface has provided insightful knowledge on the consequences work-family conflict and work-family enrichment that has served as the basis for the development of a wide range of family-focused work policies and practices that have been adopted in many organisations. However, research has largely ignored the work-home interface of employees who are single and childless. This is an unfortunate omission, because there is a worldwide increase in one-person households. Although the Singaporean government stresses the importance of family as a cornerstone of Singapore society, families here are also getting smaller and an increasing number of Singapore residents stay single and childless. To illustrate, the proportion of single and childless Singaporeans in their mid and late twenties rose from 51.7 per cent in 2000 to 71.7 per cent in 2017. Given the prevalence and (mainly negative) consequences of work-home interference and the change of family structures and living arrangements, it is important to explore the role of family structure in the work-home interface. The current study aims to develop and test a theoretical model that explores processes that may explain differences in the home-work interface that affects single and childless and married employees (with or without children).